How to set up Audition to get the best recording possible.

Hi.  I'm a complete noob so your help and understanding are greatly appreciated.

I'm using Windows 7, Samson co1u microphone, and audition cs6. 

I'd like to know how to set up audition to get the best possible recording.  I'm only recording audio for a podcast.

I'm recording in a typical 12 x 15 room in my home office.

Thanks.